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"The Complexity of Clinical Trials in the Prevention of Cardiovascular Disease: An Investigator's Perspective"

Prof Julie Buring, Prof. Dr. Dr. Tonias Kurth

Randomized clinical trials are more logistically difficult, more expensive, and need to consider more ethical issues than any other epidemiologic design strategy – yet if well designed and conducted, randomized trials can provide the highest level of assurance about the effect of the intervention itself. This lecture will address the complexity of randomized trials of prevention from an investigator’s standpoint, in the context of the evaluation of aspirin in the primary prevention of cardiovascular disease.